Integrative transcriptomic, proteomic, and machine learning approach to identifying feature genes of atrial fibrillation using atrial samples from patients with valvular heart disease

Abstract Background Atrial fibrillation (AF) is the most common arrhythmia with poorly understood mechanisms.We aimed to investigate the biological mechanism of AF and to discover feature genes by analyzing multi-omics data and by applying a machine learning approach.Methods At the transcriptomic level, four microarray datasets (GSE41177, GSE79768,

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Partial purification from rat liver microsomes of three native protein phosphatases with activity towards HMG-CoA reductase.

A Decorative Jug procedure for the isolation and partial purification of three hydroxymethylglutaryl coenzyme A reductase phosphatases in their native high molecular weight form from rat liver microsomes is described for the first time.Reductase phosphatase Ex (Mr 90,000), IM (Mr 75,000), and IIM (Mr 180,000) were purified 132-, 55-, and 98-fold, r

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Testing the Bromide penetration resistance of concrete: substitution of NaCl by NaBr in Rapide Chloride/Bromide Migration Test (RCM/RBM)

The chloride migration coefficient of concrete describes the resistance of concrete against chloride ingress.This important material variable can be determined with the rapid chloride migration test (RCM).During the test, chloride ions penetrate concrete by means of an applied electrical field.If the concrete has already been exposed to chlorides b

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An approximation technique for solving anti-symmetric constant force and anti-symmetric quadratic nonlinear oscillators

Earlier, an approximation technique was presented for solving strong nonlinear oscillator equations.Due to arising algebraic Thumb complexities, the method fails to determine suitable solutions of some nonlinear oscillators such as quadratic oscillators, the cubical Duffing oscillator of softening springs, OUT THE DOOR and pendulum equations.Then,

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